I've built over 14,000 29", fat, and Plus wheels in the last 13 years. In that time I've ridden over 50,000 trail miles on wheels I've built for myself--from hyperlight XC while racing along the spine of the continent to full-on heavy-duty while bashing and banging through the red rock desert. Plus everywhere and everything in between; gravel, sand, and snow as well as miles and miles of twisty, turny, rooty, ledgy, carvy, hoppy and flowy singletrack.
For some wheelbuilders, achieving appropriate wheel strength comes only through overbuilding with heavier-than-necessary components. Using myself as test mule I've learned that it doesn't necessarily have to be that way. Ounce of prevention? Pound of cure? When building long-lasting, quality wheels mere grams can make all the difference.
It's very likely that I have direct experience building and riding the rim/spoke/hub combo you're considering, and can steer you in the right direction if you aren't sure.
Building wheels is what I've done every day of every week for the last decade+, and my lifelong passion for riding goes into every wheel I build.
Follow my journal of current adventures HERE.